DOLINC®

1 ml contains 100 mg of doxycycline hydrochloride and 100 mg of lincomycin hydrochloride

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Pharmacological properties

Doxycycline is active against gram-positive and gram-negative microorganisms, including Staphylococcus spp., Streptococcus spp., (including St. pneumoniae), Bacillus anthracis, Listeria monocytogenes, Clostridium spp., Escherichia coli, Salmonella spp., Enterobacter spp., Shigella spp., Klebsiella spp., Bordetella spp; Corynebacterium spp., Spirochaeta spp., Mycoplasma spp., Bacteroides spp., Treponema spp., Rickettsia spp., Chlamydia psittaci, Erlichia spp. and Anaplasma spp. Lincomycin is primarily active against the majority of gram-positive microorganisms, including Staphylococcus spp., Streptococcus spp., Pneumococcus spp., Clostridium spp., Corynebacterium spp., Haemophilus spp., Bordetella spp., Actinomyces spp., Treponema hyodysenteriae and Mycoplasma spp. The mode of action of DOLINC® is based on the suppression of protein synthesis on the level of ribosomes due to the fixation of the antibiotic with the 50S-subunit of the ribosome and the inhibition of protein synthesis in the microbal cell, breaking the connection of transport aminoacyl-RNA with 30S-subunit of the ribosome membrane.

Indications

• Treatment of bacterial infections in poultry and pigs, caused by microorganisms sensitive to the combination of doxycycline and lincomycin.

Dosage

DOLINC® is administered by oral route with drinking water at a dose of 1 ml per 1 L of water for 3-5 days.

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