CLAVUXICIN®

1g contains 0.5 g of amoxicillin (in trihydrate form), 0.125 g of clavulanic acid

Pharmacological properties

Amoxicillin trihydrate has a broad spectrum of bactericidal action against gram-positive and gram-negative microorganisms, including Esherichia coli, Clostridium spp., Fusobacterium spp., Erysipilotrix spp., Bordetella spp., Staphylococcus spp., Streptococcus spp., Actynomyces spp., Corynebacterium spp., Salmonella spp., Haemophilus spp., Pausterella spp., Actinobacillus spp., etc. It has no action against penicillinase-producing strains of Klebsiella spp., Enterobacter spp. and Pseudomonas spp. Mechanism of action of amoxicillin is in violation of synthesis of the cell wall of microorganisms, inhibition of transpeptidase and carboxypeptidase, violation of osmosis, which leads to the death of the bacterial cells at the growth stage. Clavulanic acid is an irreversible inhibitor of beta-lactamases. Amoxicillin and clavulanic acid have a synergistic effect. The drug is effective against penicillin-resistant microorganisms.

Indications

• Treatment and prevention of diseases of gastrointestinal tract and respiratory system, urinary infections, skin and soft tissue diseases and other diseases in calves, pigs and poultry, caused by pathogens, sensitive to combination of amoxicillin and clavulanic acid.

Dosage

CLAVUXICIN® is administered individually or by group method for 3-5 days at the following doses:

• Poultry – 4 g per 100 kg of bw per day with drinking water. In severe cases, the dosage increased by two times.

• Pigs – 0.8-2.0 g per 100 kg of bw twice a day with drinking water, milk or mixed with feed.

• Calves – 0.8 g per 100 kg of bw twice a day with drinking water, milk or milk replacer.

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