QUINOLINE® 10% and 20%

1 ml contains 100 or 200 mg of norfloxacin

Pharmacological properties

Norfloxacin is active against wide spectrum of gram-positive and gram-negative bacteria: E. coli, Haemophilus spp., Pasteurella spp., Bordetella spp., Citrobacter spp., Enterobacter spp., Proteus mirabilis, Proteus vulgaris, Serratia spp., Neisseria gonorrhoeae, Pseudomonas aeruginosa, some strains of Aeromonas spp., Campylobacter spp., Klebsiella spp., Providencia spp., Salmonella spp., Shigella spp., Vibrio spp., Yersinia spp., Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus agalactiae, Mycoplasma spp. Mechanism of action: inhibition of DNA gyrase (II and IV type of topoisomerase), required for replication, transcription and repair of bacterial DNA, disruption of DNA and protein synthesis, which that leads to the death of the bacterial cell.

Indications

• Treatment and prevention of colibacillosis, salmonellosis, pasteurellosis, mycoplasmosis and other diseases in calves, lambs, pigs and poultry, caused by microorganisms sensitive to fluoroquinolones.

• Treatment of atrophic rhinitis, enzootic pneumonia and MMA syndrome in pigs.

Dosage

QUINOLINE® 10% and 20% is administered by oral route with drinking water as follows:

Calves, lambs and pigs: individually of by group method once a day for 3-5 days at a dose 2.5-5.0 mg/kg of bw of norfloxacine, which corresponds to 0.25-0.5 ml/10 kg of bw of a 10% solution or 0.12-0.25 ml/10 kg of bw of a 20% solution. Broilers and turkeys: 0.5 ml of 10% solution or 0.25 ml of 20% solution per 1 L of water for 3-5 days.

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