PULMOSOL®

1 g contains 350 mg of kithasamycin tartrate, 310 mg (7 350 000 IU) of colistinsulfate, 140 mg of ascorbic acid, 4 mg of glycine

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Pharmacological properties

Kithasamycin has bacteriostatic effect against gram-positive – Staphylococcus spp., Streptococcus spp. (including penicillinase-producing), Clostridium spp., Bacillus anthracis, Listeria monocytogenes and some gram-negative organisms – Haemophilus spp., Brucella spp., and Mycoplasma spp., Chlamydia spp., Rickettsia spp., etc. Mechanism of action of kithasamycin is the ability to reversibly bind to the catalytic peptidyl – transferase center of 50S ribosomal subunit and induce cleavage of the peptidyl tRNA complex. The formation process is suspended and the capacity of the peptide chain in the cells susceptible microorganisms. Colistin has a strong bactericidal effect on most aerobic gram-negative microorganisms. It possesses bactericidal activity against Enterobacter spp., Escherichia coli, Klebsiella spp., Salmonella spp., Pasteurella spp., Bordetella spp., Proteus spp. and some others, by disrupting the permeability of the cytoplasmic membrane, which leads to release in the environment of the water-soluble compounds of cytoplasm. Ascorbic acid possesses anti-stress effect and increases resistance of the organism. Glycine – neuromediatory of amino acid, part of many proteins, forms porphyrins and purine bases in the cells of the body.

Indications

• Treatment and prevention of respiratory and gastrointestinal bacterial diseases, including colibacillosis, salmonellosis, pasteurellosis, mycoplasmosis in calves, pigs and poultry.

Dosage

PULMOSOL® is administered by individual or group method with water or mixed with feed at the following doses:

• Calves: 50-100 mg/10 kg of bw once a day for 5-7 days;

• Pigs and poultry: 100-150 g per 1 000 L of drinking water for 3-5 days (individual dose 25-40 mg/10 kg of bw).

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