SOLUTYSTIN®

1 g contains 450 mg of tylosin tartrate, 6 000 000 IU (equivalent to 250 mg) of colistin sulfate

Pharmacological properties

Tylosin tartrate is active against most gram-positive and some gramnegative microorganisms, including Streptococcus spp., Leptospira spp., Corynebacterium spp., Clostridium spp., Erysipelotrix spp., Pasteurella spp., Chlamidia spp., Brachyspira (Serpulina) hyodysenteriae, Spirochaetae spp., Mycoplasma spp. Mechanism of bacteriostatic action of tylosin is in violation of protein synthesis in the microbial cell on the ribosomal level. Colistin is active against Escherichia coli, Salmonella spp., Pseudomonas aeruginosa, Pasteurella spp., Haemophilus influenzae, Acinetobacter spp., Citrobacter spp., Klebsiella spp., Shigella spp. The mechanism of antimicrobial action is in violation of the permeability of the cytoplasmic membrane, which leads to the death of microorganisms. The combination of tylosin tartrate and colistin sulphate extends the range of antimicrobial action and prevents the development of bacterial resistance to antibiotics.

Indications

• Treatment and prevention of mycoplasmosis, colibacillosis, salmonellosis and other gastrointestinal diseases of bacterial etiology, caused by pathogens, which sensitive to tylosin and colistin in poultry, pigs, calves, lambs and goats. Dosage SOLUTYSTIN® is administered individually or by group method with drinking water for 3-5 days at following daily doses:

• Pigs , calves and lambs – 3- 4 g per 100 kg of bw;

• Poultry – 250-500 g per 100 liters of drinking water. In severe cases, the dosage should be doubled.

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