TIACYCLIN® oral solution

1 ml contains 100 mg of doxycycline and 100 mg of tiamulin

Indications

The drug is used for treatment and prevention of bacterial diseases (pasteurellosis, salmonellosis, colibacillosis, etc.) in pigs, calves, lambs, goatlings and poultry caused by bacteria susceptible to tiamulin and doxycycline.

 Composition

1 ml of TIACYCLIN contains 100 mg of doxycycline and 100 mg of tiamulin.

Pharmacological properties

Tiamulin is a macrolide antibiotic. It is active against Mycoplasma spp. (M. hyopneumoniae, M. hyorhinis, M. hyosynoviae, M. synoviae, M. meleagridis), Borrelia spp. (Brachyspira hyodysenteriae, B. innocents, B. suis), most gram-positive and gram-negative bacteria, including Streptococcus spp., Staphylococcus spp., Arcanobacterium (Corynebacterium), Actinobacillus pleuropneumoniae, Clostridium perfringens, Lawsonia intracellularis, Mannheimia haemolitica, Pasteurella spp., Leptospira spp., Haemophillus spp., Bacterioides spp.

Forming a physiologically inactive initiation complex, tiamulin blocks the first peptide-bond formation at the ribosomal level. The molecule of tiamulin is located in the peptidyl transferase center of the 50S ribosomal subunit.

Doxycycline is a tetracycline antibiotic. It is active against gram-positive bacteria (Staphylococcus spp., Streptococcus spp., Actinomyces spp., Clostridium spp., Bacillus anthracis, Corynebacterium spp., Erysipelothrix spp., Listeria spp.) and gram-negative bacteria (Haemophilus influenza, Haemophilus parasuis, Pasteurella multocida, Bordetella spp., Bartonella spp., Actinobacillus pleuropneumoniae, Campylobacter spp.), Mycoplasma spp. (M. hyopneumoniae, M. hyorhinis, M. hyosynoviae, M. synoviae) and Borrelia spp., Chlamydia spp., Rickettsia spp.

Disrupting the binding of the aminoacyl-tRNA to the 30S ribosomal subunit, doxycycline inhibits protein synthesis in a bacterial cell.

After administration, tiamulin and doxycycline are absorbed from the injection site and distributed to all organs and tissues, where they provide therapeutic concentration for 24 hours.

Tiamulin is excreted mainly in the bile and to a lesser extent in the urine. Doxycycline is mainly excreted in the bile.

 Dosage and Administration

Tiacyclin is administered once a day within 3-5 days at the following doses:

·         Livestock and poultry: 0.5-1 L/1000 L of drinking water, in severe cases – 2 L/1000 L of drinking water;

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