Coliquinol® is an antibacterial and antiprotozoal drug. The components of Coliquinol® have a synergistic effect on grampositive and gram-negative bacteria, including Staphylococcus spp., Streptococcus spp. (including penicillinase-producing strains), Corynebacterium spp., Clostridium spp., Haemophilus spp., Klebsiella spp., Proteus spp., Salmonella spp., Pasteurella spp., Brucella spp., Shigella spp., Esherichia coli, Pseudomonas aeruginosa, Aerobacter aerogenes, Neiseria gonorrhoeae, and Bacteroides spp., Mycoplasma, large viruses, Coccidia, Toxoplasma, Actinomycetales. The synergistic effect of sulfamethoxazole and trimethoprim combination inhibits folic acid synthesis in the bacterial cell, which leads to the inhibition of nucleotide synthesis. After oral administration, lincomycin, sulfamethoxazole and trimethoprim are absorbed in the gastrointestinal tract and distributed to organs and tissues. Colistin is hardly absorbed in the gastrointestinal tract and has its antimicrobial effect directly in the intestine. Lincomycin and colistin are excreted intact, mainly in the urine and feces, sulfamethoxazole and trimethoprim – mainly in the urine.
Coliquinol® is used to treat poultry and pigs for bacterial, mycoplasma, protozoan infections caused by bacteria sensitive to the drug components.
1 ml contains 50 mg of sulfamethoxazole, 50 mg of lincomycin hydrochloride, 400 000 IU of colistin sulfate, 10 mg of trimethoprim and excipients.
Coliquinol® is administered to pigs and poultry individually or to groups via drinking water at a dose of 1000-1500 ml/t of water. The treatment course is 3-5 days.