Florfenicol is a synthetic antibiotic, thiamphenicol derivative. The
hydroxyl group is substituted by a fluorine atom. Florfenicol is a
broad-spectrum bacteriostatic antibiotic. The antibiotic binds to the
50S ribosomal subunit, blocks peptidyl transferase activity, and as a
result it leads to the inhibition of protein synthesis.
Florfenicol is active against gram-positive and gram-negative bacteria,
Staphylococcus spp., Streptococcus spp., Escherichia coli, Salmonella spp.,
Actinobacillus pleuropneumoniae, Pasteurella multocida, Pasteurella
haemolitica, Haemophilus spp., Fusobacterium necrophorum, Proteus
spp., Enterobacter spp., Shigella spp., Klebsiella spp., Bordetella spp., as
well as Mycoplasma spp.
Florfenicol is active against bacteria producing acetyltransferase and
bacteria resistant to chloramphenicol. After parenteral administration,
florfenicol is quickly absorbed and distributed to all organs and
tissues. The antibiotic reaches the maximum concentration in 30-90
minutes, the therapeutic concentration persists for 48 hours.
Flunixin meglumine is a nonsteroidal anti-inflammatory drug with
antipyretic, analgesic, and anti-inflammatory effects. Flunixin is an
inhibitor of cyclooxygenase, as a result, it reduces prostaglandin
It reduces the inflammation and pain caused by musculoskeletal
disorders and colic. Flunixin meglumine is rapidly absorbed and has
a long-lasting effect.
The therapeutic effect is achieved in 2 hours after administration, the
maximum concentration is reached in 12-16 hours, the duration of
action is 36 hours.
Florfenicol and its metabolites are excreted primarily in the urine and
to a lesser extent in the feces.
Flunixin meglumine is mainly excreted by the kidneys.
1 ml of solution for injection contains 300 mg of florfenicol and 16.3 mg of flunixin meglumine.
Floricol® solution for injection is administered to cattle by intramuscular route, twice with a 48-hour interval at a dose of 1 ml per 15 kg bw (20 mg of florfenicol per 1 kg). It is possible to administer a single subcutaneous injection into the neck region at a dose of 2 ml per 15 kg bw (40 mg of florfencol per 1 kg). The drug is administered to pigs intramuscularly into the neck region twice with a 48-hour interval at a dose of 1 ml per 20 kg bw (15 mg of florfenicol per 1 kg). It is not allowed to administer more than 15 ml of the drug per one injection site.