1 ml contains 100 mg of enrofloxacin and 2000000 IU of colistinsulfate


Pharmacological properties

Enrofloxacin possesses a wide spectrum of antibacterial and antimycoplasmal action against gram-positive and gram-negative microorganisms, including E. coli, Haemophilus spp., Klebsiella spp., Pasteurella spp., Pseudomonas spp., Bordetella spp., Campylobacter spp., Erysipelothrix spp., Corynebacterium spp., Staphylococcus spp., Streptococcus spp., Actinobacillus spp., Clostridium spp., Bacteroides spp., Fusobacterium spp., and Mycoplasma spp. Bacteria resistance to ENROFLON-K® develops relatively slowly, as the mechanism of antimicrobial action of enrofloxacin is based on the inhibition of the activity of gyrase ferment affecting the DNA replication in the core of the bacterial cell. Colistin has bactericidal action against gram-negative bacteria, including E. coli, Haemophilus spp. and Salmonella spp. Polymyxins interact strongly with phospholipids and penetrate into and disrupt the structure of cell membranes. They disorganize the outer membrane of gram-negative bacteria by binding lipopolysaccharide (LPS, endotoxin) through direct interaction with the anionic lipid A region, thereby neutralizing the endotoxin capacity of LPS. Indications

• Treatment and prevention of respiratory and gastro-intestinal infections of bacterial etiology, colibacteriosis, salmonellosis, enteritis, mycoplasmosis, mixed and secondary infections in piglets and poultry, caused by microorganisms are sensitive to fluorquinolones and colistin.


ENROFLON-K® is administered by oral route with drinking water as follows: Piglets: individually or by group method at a dose of 0.3 ml/kg-bw/day for 2-3 days; Poultry: 0.5-1.0 ml per 1 L of water for 3-5 days.

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