Colimixol®
Oral granules
Specification
Colimixol® is an antibacterial drug, belongs to polypeptide antibiotics. Colistin sulfate is effective against gram-negative bacteria, including Е. coli, Pseudomonas aeruginosa, Aerobacter aerogenes, Klebsiella spp., Proteus spp., Salmonella spp., etc. The antibiotic disrupts cytoplasmic membrane permeability, which leads to death of bacterial cell. After oral administration, colistin is hardly absorbed in the gastrointestinal tract and has its antimicrobial effect directly in the intestine. Colistin is mainly excreted intact in the urine and feces.
Indications
Colimixol® is used to treat poultry, pigs and calves for colibacillosis, salmonellosis and other gastrointestinal diseases of bacterial etiology, caused by colistin-sensitive bacteria.
Composition
1 g contains 1.8 million IU (200 mg), 2.4 million IU (100 mg), 1.2 million IU (50 mg) of colistin sulfate and excipients – up to 1 g. is used to treat poultry, pigs and calves for colibacillosis, salmonellosis and other gastrointestinal diseases of bacterial etiology, caused by colistin-sensitive bacteria.
Dosage
Colimixol® is administered via feed at the following daily doses:
|
Drug |
Poultry |
Pigs |
Calves |
|
Colistin |
75 000 IU/kg bw |
100 000 IU/kg bw |
100 000 IU/kg bw |
|
COLIMIXOL® 4.8 million IU |
0.2-0.3 kg/t of feed |
0.75 kg/t of feed |
20 mg/kg bw |
|
COLIMIXOL® 2.4 million IU |
0.4-0.6 kg/t of feed |
1.5 kg/t of feed |
40 mg/kg bw |
|
COLIMIXOL® 1.2 million IU |
0.8-1.2 kg/t of feed |
3 kg/t of feed |
80 mg/kg bw |