Specification
Colimixol® belongs to the class of polypeptide antibiotics.
Colistin sulfate is active against gram-negative bacteria, including
Е. coli, Pseudomonas aeruginosa, Aerobacter aerogenes, Klebsiella spp.,
Proteus spp., Salmonella spp., etc. The antibiotic disrupts cytoplasmic
membrane permeability. It causes death of bacteria.
After oral administration, colistin is hardly absorbed in the
gastrointestinal tract, the antimicrobial effect is provided directly in
the intestine. Colistin is excreted intact mainly in the urine and feces.
Indications
Colimixol® is used to treat poultry, pigs and calves for colibacillosis, salmonellosis and other gastrointestinal diseases caused by colistinsensitive bacteria.
Composition
1 g contains active substances: 12 million IU (500 mg) and 6 million IU (250 mg) of colistin sulfate; excipients: ascorbic acid, citric acid, glycine and lactose.
Dosage
Colimixol® is administered individually or by group method with drinking water or feed for 3-5 days at a daily dose:
|
Drug |
Poultry |
Pigs and calves |
|
COLIMIXOL® 12 million IU |
50-75 g / 1000 L |
60-80 mg / 10 kg bw |
|
COLIMIXOL® 6 million IU |
100-150 g / 1000 L |
120-160 mg / 10 kg bw |
The treatment course is 3-5 days.