Doxyprem 100, 200
Oral granules
Specification
Doxyprem 100, 200 is an antibacterial drug.
Doxycycline hyclate or hydrochloride is a semisynthetic tetracycline
antibiotic. It is effective against most gram-positive (Staphylococcus spp., Streptococcus spp., Actinomyces spp., Clostridium spp., Bacillus
anthracis, Corynebacterium spp., Erysipelothrix spp., Listeria spp.)
and gram-negative bacteria (Haemophilus influenzae, Haemophilus
parasuis, Pasteurella multocida, Bordetella spр., Brucella spр., Bartonella
spр., Actinobacillus pleuropneumoniae, Escherichia coli, Salmonella spp.,
Campylobacter spp.) and Mycoplasma spp. (M. synoviae, М. gallisepticum,
M. hyopneoumonia, M. hyorhinis, M. hyosynoviae), Chlamydia spp.,
Rickettsia spp. It is a bacteriostatic drug. Doxycycline inhibits protein
synthesis, disrupts the binding of aminoacyl-RNA to the 30S ribosomal
subunit.
After oral administration, doxycycline is well absorbed in the
gastrointestinal tract and distributed to all organs and tissues.
Doxycycline is mainly excreted in the bile, feces, urine and eggs.
Indications
Doxyprem 100, 200 is used for treatment and prevention of bacterial diseases of gastrointestinal and respiratory tract in pigs, poultry, calves, lambs and goatlings caused by doxycycline-sensitive bacteria.
Composition
1 g contains 100 or 200 mg of doxycycline hyclate or hydrochloride and excipients.
Dosage
Doxyprem 100, 200 is administered via feed for 5-7 days at the following daily doses:
|
Animal species |
DOXYPREM 100 |
DOXYPREM 200 |
||
|
Pigs |
2-3 kg/1000 kg of feed |
100-150 mg/ kg bw |
1-1.5 kg/1000 kg of feed |
50-75 mg/ kg bw |
|
Poultry |
1-1.5 kg/1000 kg of feed |
100-120 mg/ kg bw |
0.5-0.75 kg/1000 kg of feed |
50-60 mg/ kg bw |
|
Calves, lambs, goatlings |
|
50-100 mg/ kg bw |
|
25-50 mg/ kg bw |