Enrofloxacin belongs to the fluoroquinolone class. It is a broadspectrum antibiotic, effective against gram-positive and gramnegative bacteria, including E.coli, Haemophilus spp., Klebsiella spp., Pasteurella spp., Pseudomonas spp., Bordetella spp., Campylobacter spp., Erysipelothrix spp., Corynebacterium spp., Staphylococcus spp., Streptococcus spp., Actinobacillus spp., Clostridium spp., Bacteroides spp., Fusobacterium spp. and Mycoplasma spp. The resistance of bacteria to ENROFLON® powder develops relatively slow, because enrofloxacin inhibits gyrase activity, which has an impact on DNA replication in the bacterial cell nucleus. The maximum concentration is reached in 1-2 hours after administration and persists for 6 hours, the therapeutic concentration persists for 24 hours. Fluoroquinolo-nes are mainly excreted in the urine and bile.
• treatment and prevention of colibacillosis, salmonellosis mycoplasmosis, bronchopneumonia, enteritis and other diseases in calves, lambs, pigs and poultry caused by fluoroquinolonesensitive bacteria
• treatment of atrophic rhinitis, enzootic pneumonia and mastitismetritis-agalactia syndrome in pigs.
1 g of Enroflon® 5% and 10% contains 50 or 100 mg of enrofloxacin, respectively.
The drug is administered via feed at a dose of 2.5-5.0 mg of enrofloxacin per 1 kg bw, once a day for 3-5 days. ENROFLON® powder is administered to poultry via feed at a dose of 2 kg of Enroflon® 5% powder (or 1 kg of ENROFLON® 10% powder) per 1 t of feed, to pigs – 1.5 kg of Enroflon® 5% powder (or 0.75 kg of Enroflon® 10% powder) per 1 t of feed. To treat salmonellosis and in severe cases, the dose is doubled.