Enroflon®-К
Oral solution
Specification
Enroflon®-К is an antimicrobial drug.
Enrofloxacin is a quinolone-carboxylic acid derivative, belongs
to the third-generation fluoroquinolones. The antibiotic has a
broad-spectrum bactericidal effect on most gram-positive and
gram-negative bacteria, including Escherichia coli, Salmonella spp.,
Enterobacter spp., Proteus mirabilis, Proteus vulgaris, Haemophilus spp.,
Klebsiella, Pasteurella multocida, Pseudomonas aeruginosa, Bordetella,
Campylobacter, Erysipelothrix, Corynebacterium, Staphylococcus
spp., Streptococcus spp., Actinobacillus, Clostridium, Fusobacterium,
Bacteroides and Mycoplasma spp.
Enrofloxacin inhibits DNA gyrase activity, DNA synthesis, bacterial
growth and division; causes evident morphological changes (in cell
walls and membranes). It causes death of bacteria.
Colistin sulfate is a polymyxin E, belongs to cyclic polypeptide
antibiotics. By modifying the structure and functions of outer and
cytoplasmic membranes, colistin has a bactericidal effect on gramnegative bacteria at the stage of division and resting. The antibiotic
is active against Escherichia coli, Salmonella spp., Pseudomonas
aeruginosa, Pasteurella spp., Haemophilus spp., Acinetobacter spp.,
Citrobacter spp., Klebsiella spp., Shigella spp.
The combination of enrofloxacin and colistin has a synergistic effect
due to the different mechanisms of bactericidal effect. The resistance
to the antibiotics develops slowly.
After oral administration, enrofloxacin is quickly absorbed in the
gastrointestinal tract and distributed to all organs and tissues.
Enrofloxacin reaches the maximum concentration in the blood in 1-2
hours. Colistin sulfate is poorly absorbed and has its antimicrobial
effect directly in the intestine.
Enrofloxacin is excreted mainly intact and as ciprofloxacin. Colistin is
excreted intact mainly in the urine and feces.
Indications
Enroflon®-К is used for treatment and prevention of bacterial
diseases of respiratory and gastrointestinal tract, including
colibacillosis, salmonellosis, enteritis, mycoplasmosis, mixed and
secondary infections in poultry caused by bacteria sensitive to
enrofloxacin and colistin.
Composition
1 ml contains
active substances: 100 mg of enrofloxacin and 2 000 000 IU of
colistin sulfate;
excipients: 187.5 mg of lactic acid, 150 mg of propionic acid, 90 mg
of propylene glycol, 10 mg of ascorbic acid and distilled water-up to
1 ml.
Dosage
Enroflon®-К is administered via drinking water at a dose of 0.5-1 ml per 1 L of water for 3-5 days.