Flox-O-Quin®
Oral solution
Specification
Flox-O-Quin® is an antibacterial drug of the second-generation
fluoroquinolones. Ofloxacin is a broad-spectrum antibiotic, has a
bacteriostatic effect. The antibiotic is active against gram-positive
and gram-negative bacteria, including Escherichia coli, Salmonella
spp., Shigella spp., Enterobacter spp., Klebsiella spp., Proteus spp.,
Campylobacter spp., Pseudomonas aeruginosa, Haemophilus spp.,
Staphylococcus spp. and Mycoplasma spp. Ofloxacin inhibits DNA
gyrase activity (type II topoisomerase). After oral administration,
ofloxacin is quickly absorbed in the gastrointestinal tract and
distributed to most organs and tissues, reaches the maximum
concentration in the lungs, liver and kidneys. The maximum
concentration in the blood serum is detected in 1.5-2 hours after
administration. The therapeutic concentration persists for 24 hours.
The antibiotic is metabolized and excreted intact (80%) in the urine
and bile.
Indications
Flox-O-Quin® is used to treat calves, goatlings, lambs, pigs, cats,
dogs and poultry for bacterial diseases of respiratory and genitourinary
system, gastrointestinal tract, arthritis, colibacillosis, salmonellosis,
streptococcosis, septicemia, necrotic enteritidis, peritonitis, secondary
and mixed infections caused by fluoroquinolone-sensitive bacteria.
Composition
1 ml contains active substance: 100 mg of ofloxacin; excipients: acetic acid, propylene glycol, propionic acid, thioglycerin and purified water – up to 1 ml.
Dosage
Flox-o-quin® is administered individually and to groups by oral route for 3-5 days, at the following doses:
• calves, goatlings, lambs, pigs, cats and dogs: via drinking water or milk replacer, at a dose of 0.5 ml of the drug per 10 kg bw;
• broilers, replacement chickens and turkeys: via drinking water, at a dose of 50 ml of the drug per 100 L of water;
• to treat salmonellosis, mixed infections and chronic diseases, the dose for poultry is 100 ml per 100 L of water for 5 days.