Lactico
Suspension for intracisternal administration
Specification
Lactico is a combined antibacterial drug for intracisternal administration, which includes amoxicillin, which belongs to the
antibiotics from the penicillin group, prednisolone, a short-acting
synthetic glucocorticosteroid, and clavulanic acid.
Amoxicillin trihydrate is a semi-synthetic antibiotic of the penicillin
group, has a broad spectrum of bactericidal action against grampositive and gram-negative microorganisms secreted from the udder
with mastitis, including Staphylococcus spp., Streptococcus agalactiae,
Streptococcus uberis, Streptococcus dysgalactiae, Corynebacterium
pyogenes, Escherichia coli, Bacillus cereus, Bacteroides spp.,
Campylobacter spp., Klebsiella spp., Pasteurella spp.
The mechanism of action of amoxicillin is to disrupt the synthesis
of the cell wall of the microorganism, to inhibit the enzymes
transpeptidase and carboxypeptidase, to disrupt osmosis, which
leads to the death of a bacterial cell at the growth stage.
Clavulanic acid is an irreversible β-lactamase inhibitor. By joining
bacterial enzymes, it forms stable, inactive complexes, preventing
the decomposition of amoxicillin by enzymes.
Amoxicillin and clavulanic acid have a synergistic effect. Due to this,
the drug is effective against penicillin-resistant microorganisms.
Prednisolone has an anti-inflammatory effect, reducing swelling and
inflammation of tissues.
After intracisternal administration, the drug creates a high level
of antibiotic in the tissues of the udder, without irritating. The
therapeutic concentration of the antibiotic is maintained for 12 hours.
The active components of the drug are excreted from the body with
urine and feces, in lactating animals – with milk.
Indications
Lactico is prescribed for the treatment of subclinical and clinical
mastitis of bacterial etiology in lactating cows.
Composition
One syringe dispenser for intracisternal administration with a mass of
3 g contains 200 mg of amoxicillin (as trihydrate), 50 mg of clavulanic
acid (as potassium salt), 10 mg of prednisolone, and excipients
(colloidal silicon dioxide, benzyl alcohol, butylhydroxytoluene,
miglyol 812 N – up to 3 g). The drug is produced at 3 g in polyethylene
syringe dispensers, hermetically sealed with caps, which are packed
together with cleaning disposable wipes in cardboard boxes of
24 pieces.
Dosage
Before the administration of the drug, the infected quarter of the
udder is completely freed from milk and the nipple is carefully treated
with an antiseptic or a special antiseptic napkin supplied with the
drug. Then remove the cap from the tip of the syringe dispenser,
insert the tip into the nipple canal and gently squeeze the contents
of one syringe dispenser into the infected quarter of the udder. After
that, the syringe is removed, the tip of the nipple is squeezed and the
udder nipple is massaged from bottom to top for better distribution
of the drug.
Lactico is administered three times with an interval of 12 hours.