Florfenicol is a synthetic antibiotic, thiamphenicol derivative, where
hydroxyl groups are substituted by fluorine atoms.
Florfenicol has a bacteriostatic effect on gram-positive (Staphylococcus spp., Streptococcus spp.,) and gram-negative (Escherichia coli,
Salmonella spp., Pasteurella multocida, Haemophilus spp., Proteus
spp., Enterobacter spp., Klebsiella spp., Bordetella spp., Moraxella
spp. and Mycoplasma spp.) bacteria. Florfenicol is active against bacteria producing acetyltransferase and bacteria resistant to
chloramphenicol. Florfenicol binds to the 50S ribosomal subunit in
the bacterial protoplasm, where the antibiotic blocks the enzyme
peptidyl transferase, as a result it inhibits protein synthesis.
Levamisole belongs to anthelmintics of the imidazole group, it is
active against nematodes. Levamisole affects the neuromuscular
system, inhibits fumarate reductase, which causes paralysis and
death of parasites. Levamisole is an immunostimulant, it stimulates
regeneration processes in tissues, has no cumulative, embryotoxic,
teratogenic, mutagenic, carcinogenic effects.
• to treat cattle, sheep and goats for thelaziosis;
• to treat livestock, cats and dogs for conjunctivitis;
• to treat infected wounds in livestock and pets.
1 g contains 10 mg of florfenicol and 10 mg of levamisole hydrochloride.
To treat thelaziosis and conjunctivitis, Mizofen®-F is administered to the conjunctival sac of the infected eye at a dose of 0.1-0.5 g twice a day. The treatment course must not exceed 5-7 days. To treat infected wounds, Mizofen®-F is administered to the affected area 1-2 times a day, until the wound is completely cleared of purulonecrotic masses. The average course of treatment is 10 days.