Paraterm
Water-soluble powder for oral administration
Specification
Acetylsalicylic acid has an anti-inflammatory, antipyretic, analgesic
effect, and prevents thrombosis.
The mechanism of anti-inflammatory and analgesic action is based
on a disruption of the synthesis of bradykinin and prostaglandins,
as well as on the effect on pain receptors in the peripheral nervous
system. The antipyretic effect is due to the effect on the production
of endogenous pyrogen (interleukin 1) by leukocytes and increased
heat elimination.
The anti-aggregatory effect of acetylsalicylic acid is associated with
blocking the metabolism of arachidonic acid, which activates the
synthesis of prostacyclin, which inhibits platelet aggregation and
thereby prevents thrombosis.
After oral administration of Paraterm (water-soluble powder),
acetylsalicylic acid is rapidly absorbed in the gastrointestinal tract
and distributed to most organs and tissues of the body. The drug
metabolized in the liver with the formation of salicyluric acid,
salicylglucuronide and gentisic acid.
Paraterm is excreted from the body mainly with urine.
Indications
Paraterm (water-soluble powder) is used as an analgesic, antiinflammatory and antipyretic drug for poultry, pigs and calves in
pathological conditions accompanied by inflammatory and pain
symptoms, including respiratory and gastrointestinal diseases,
metritis-mastitis-agalactiae syndrome, rheumatoid arthritis,
osteoarthritis, muscle and postoperative pain and heat stress.
Composition
1 g contains active substance: 750 mg of acetylsalicylic acid; excipients: sodium carbonate – 150 mg, potassium carbonate –100 mg.
Dosage
Paraterm is administered with drinking water for 3-5 days at a dose per day:
- for poultry: 0.07 g of the drug/kg of bw, which corresponds to 50 mg of acetylsalicylic acid/kg of bw, or 250-550 g of the drug per ton of water;
- pigs: 0.13 g of the drug/kg of bw, which corresponds to 100 mg of acetylsalicylic acid/kg of bw, or 1300-2000 g of the drug per ton of water;
- calves: 0.07 g of the drug/kg of bw per day, which corresponds to 50 mg of acetylsalicylic acid/kg of live weight.
Fresh solution of the drug should be prepared daily.
Avoid missing the next dose of the drug, as this may lead to a decrease in therapeutic efficacy. In case of missing one dose, the use of the drug is resumed in the same dosage and according to the same schedule.