Quinoline®
Oral solution
Specification
Quinoline® is an antimicrobial drug of the fluoroquinolone class.
Norfloxacin is a synthetic analogue of nalidixic acid, pefloxacin
metabolite, has a bactericidal effect. The antibiotic inhibits activity of
DNA gyrase (type II and IV topoisomerase) necessary for replication,
transcription and repair of bacterial DNA. The antibiotic inhibits
synthesis of DNA and proteins, which leads to death of bacteria.
Norfloxacin is active against a wide range of gram-positive and gramnegative bacteria: E. coli, Haemophilus spp., Pasteurella spp., Bordetella
spp., Citrobacter spp., Enterobacter spp., Proteus mirabilis, Proteus vulgaris, Serratia spp, Neisseria gonorrhoeae, Pseudomonas aeruginosa,
some strains of Aeromonas spp., Campylobacter spp., Klebsiella spp.,
Providencia spp., Salmonella spp., Shigella spp., Vibrio spp., Yersinia spp.,
Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus
agalactiae, Mycoplasma spp.
After oral administration, norfloxacin is quickly absorbed in the
gastrointestinal tract and distributed to most organs and tissues,
the highest concentration is reached in the lungs, liver and kidneys.
The maximum concentration is reached in 1-2 hours and persists for
6 hours. The therapeutic concentration persists for 24 hours after
administration. Norfloxacin is metabolized and excreted intact in the
urine and bile.
Indications
Quinoline® is used for treatment and prevention of colibacillosis,
salmonellosis, pasteurellosis, haemophillosis, mycoplasmosis,
atrophic rhinitis and other diseases in calves, lambs, pigs and poultry
caused by fluoroquinolone-sensitive bacteria. The drug is also used
to treat pigs for mastitis-metritis-agalactia syndrome.
Composition
1 ml contains active substance: 100 mg or 200 mg of norfloxacin base;
excipients: 100 mg of acetic acid, 100 mg of propylene glycol, 5 mg
of propionic acid, 1 mg of thioglycerin and purified water – up to 1 ml.
Dosage
Quinoline® 10% and 20% is administered to calves, lambs and pigs individually or to groups via drinking water at a dose of 2.5-5.0 mg of norfloxacin per 1 kg bw (0.25-0.5 ml of 10% solution per 10 kg bw or 0.12-0.25 ml of 20% solution per 10 kg bw) for 3-5 days.
Quinoline® 10% and 20% is administered to turkeys and broilers at a dose of 0.5 ml of 10% solution per 1 L of water or 0.25 ml of 20% solution per 1 L of water for 3-5 days.
To treat salmonellosis, the dose can be doubled.