Solutistin®

Specification

Solutistin® is an antimicrobial drug, its active substances are
tylosin tartrate and colistin sulfate.
Tylosin tartrate is a macrolide antibiotic, active against most
gram-positive and some gram-negative bacteria, including
Streptococcus spp., Leptospira spp., Corynebacterium spp., Clostridium
spp., Erysipelotrix spp., Pasteurella spp., Chlamidia spp., Brachyspira
(Serpulina) hyodysenteriae, Spirochaetae spp., Mycoplasma spp. The
antibiotic has a bacteriostatic effect, inhibits protein synthesis at the
ribosomal level in the bacterial cell.
Colistin is a polymyxin E, belongs to cyclic polypeptide antibiotics,
active against Escherichia coli, Salmonella spp., Citrobacter spp.,
Klebsiella spp., Shigella spp., etc. The antibiotic disrupts cytoplasmic
membrane permeability. It causes death of bacteria.
The combination of tylosin tartrate and colistin sulfate expends the
range of antimicrobial activity and prevents the development of
resistance to the antibiotics.
After oral administration, colistin is hardly absorbed in the
gastrointestinal tract and has its antimicrobial effect directly in
the intestine. Colistin is excreted intact mainly in the feces. Tylosin
tartrate is absorbed in the gastrointestinal tract and distributed
to most organs and tissues. The therapeutic concentration of the
antibiotic persists for 15-18 hours after a single administration.
Tylosin tartrate is metabolized and excreted intact in the urine and
feces.