Terpentiam® 45%
Oral powder
Specification
Terpentiam® 45% is an antibacterial drug, belongs to
pleuromutilins.
Tiamulin is a broad-spectrum antibiotic, effective against grampositive (Staphylococcus spp., Streptococcus spp., Listeria monocytogenes,
Corynebacterium spp., Erysipelothrix suis, Clostridium spp., etc.) and
gram-negative bacteria (Actinobacillus pleuropneumoniae, Lawsonia
intracellularis, Mannheimia haemolitica, Pasteurella spp., Haemophillus
spp., Brachyspira (Serpulina) hyodysenteriae, Bacteroides spp.,
Fusobacterium spp., some strains of Klebsiella spp., etc), Mycoplasma
spp. (M. hyopneumoniae, M. hyosinoviae, M. hyorhinis, M. gallisepticum,
M. synoviae, M. meleagridis), Chlamydia spp., Rickettsia spp. and Borrelia
spp.
The drug is not active against most Enterobacteriaceae bacteria,
including Salmonella spp., E. coli, Pseudomonas aeruginoza, fungi and
viruses.
Tiamulin is a bacteriostatic drug. It binds to the 70S ribosomal
subunit, inhibits the formation of the mRNA-tRNA complex and
protein synthesis.
After oral administration, the drug is well absorbed in the
gastrointestinal tract and distributed to all organs and tissues.
The maximum concentration in the blood serum is reached in
2 hours. The therapeutic concentration persists for 18-24 hours after
administration. The antibiotic is mainly excreted in the feces.
Indications
The drug is used for treatment and prevention of diseases of the
gastrointestinal and respiratory tract, including dysentery, enzootic
pneumonia, proliferative enteropathy (ileitis) in pigs and mycoplasma
infections, caused by M. gallisepticum, M. synoviae и M. meleagridis, in
turkeys and chickens.
Composition
1 g of the drug contains active substance: 450 mg of tiamulin hydrogen fumarate; excipients: glycine, tartaric acid, citric acid, EDTA and lactose – up to 1 g.
Dosage
Terpentiam® 45% is administered individually and to groups via drinking water or feed at the following doses:
Pigs
• to treat diseases of the gastrointestinal tract: 5-10 mg of tiamulin per 1 kg bw, which corresponds to 1.1-2.2 g of the drug per 100 kg bw, for 3-5 days
• to treat diseases of the respiratory tract: 10-20 mg of tiamulin per 1 kg bw, which corresponds to 2.2-4.4 g of the drug per 100 kg bw, for 5-10 days.
Poultry:
• 1-3 day old chickens: 70-150 mg of tiamulin per 1 kg bw, which corresponds to 1.6-3.4 g of the drug per 10 kg bw
• broilers, replacement chickens, parent flock: 25-50 mg of tiamulin
per 1 kg bw, which corresponds to 0.5-1.1 g of the drug per
10 kg bw, within 1-3 days for prevention and within 3-5 days for
treatment.