Terpentiam® premix 10%
Oral granules
Specification
Terpentiam® premix 10% is an antibacterial drug.
Tiamulin is a semisynthetic antibiotic of the pleuromutilin class.
It is a broad-spectrum antibiotic, effective against gram-positive
(Staphylococcus spp., Streptococcus spp., Listeria monocytogenes,
Corynebacterium spp., Erysipelothrix suis, Clostridium spp., etc.) and
gram-negative bacteria (Actinobacillus pleuropneumoniae, Lawsonia
intracellularis, Mannheimia haemolitica, Pasteurella spp., Haemophillus spp., Brachyspira (Serpulina) hyodysenteriae, Bacteroides spp.,
Fusobacterium spp., some strains of Klebsiella spp., etc), Mycoplasma spp.,
Chlamydia spp., Rickettsia spp. and Borrelia spp. The drug is not active
against most Enterobacteriaceae bacteria, including Salmonella spp.,
E. coli, Pseudomonas aeruginoza, fungi and viruses.
Tiamulin is a bacteriostatic antibiotic. It binds to the 70S ribosomal
subunit, inhibits the formation of the mRNA-tRNA complex and
protein synthesis.
After oral administration, the drug is well absorbed in the
gastrointestinal tract and distributed to all organs and tissues.
The maximum concentration in the blood serum is reached in
2 hours. The therapeutic concentration persists for 18-24 hours after
administration. The antibiotic is mainly excreted in the feces.
Indications
Terpentiam® premix 10% is used for treatment and prevention
of gastrointestinal and respiratory diseases, including dysentery,
enzootic pneumonia, proliferative enteropathy (ileitis) in pigs.
Composition
1 g contains 100 mg of tiamulin hydrogen fumarate and excipients.
Dosage
Terpentiam® premix 10% is administered via feed at the following daily doses:
|
Drug |
Dose |
|
Tiamulin |
6-8 mg/kg bw |
|
TERPENTIAM® premix 10% |
1-1.5 kg/t of feed |
for treatment – 7-10 days;
for treatment and prevention – 10-14 days. In severe cases, the dose can be doubled.