Terpentiam® premix 80%
Oral powder
Specification
Terpentiam® premix 80% is an antibacterial drug.
Tiamulin is a semisynthetic antibiotic of the pleuromutilin class.
It is a broad-spectrum antibiotic, effective against gram-positive
(Staphylococcus spp., Streptococcus spp., Listeria monocytogenes,
Corynebacterium spp., Erysipelothrix suis, Clostridium spp., etc.) and
gram-negative bacteria (Actinobacillus pleuropneumoniae, Lawsonia
intracellularis, Mannheimia haemolitica, Pasteurella spp., Haemophillus
spp., Brachyspira (Serpulina) hyodysenteriae, Bacteroides spp.,
Fusobacterium spp., some strains of Klebsiella spp., etc), Mycoplasma
spp., Chlamydia spp., Rickettsia spp. and Borrelia spp. The drug is not
active against most Enterobacteriaceae bacteria, including Salmonella
spp., E. coli, Pseudomonas aeruginoza, fungi and viruses.
Tiamulin is a bacteriostatic agent. It binds to the 70S ribosomal
subunit, inhibits the formation of the mRNA-tRNA complex and
protein synthesis.
After oral administration, the drug is well absorbed in the
gastrointestinal tract and distributed to all organs and tissues.
The maximum concentration in the blood serum is reached in
2 hours. The therapeutic concentration persists for 18-24 hours after
administration. The antibiotic is mainly excreted in the feces.
Indications
Terpentiam® premix 80% is used for treatment and prevention of diseases of gastrointestinal and respiratory tract in pigs, including dysentery, enzootic pneumonia, proliferative enteropathy (ileitis).
Composition
1 g contains active substance: 800 mg of tiamulin hydrogen fumarate; excipients: tartaric acid, citric acid, glycine, trilon B and lactose – up to 1 g.
Dosage
Terpentiam® premix 80% is administered via feed within 7-10 days for treatment and within 10-14 days for treatment and prevention at the following daily doses:
|
Drug |
Dose |
|
Tiamulin |
6-8 mg/kg bw |
|
TERPENTIAM® premix 80% |
0.125-0.188 kg/t of feed |
In severe cases, the dose can be doubled.