Tetramisol 10% and 20%
Oral powder
Specification
The active substance is a racemic mixture of two optical isomers
D and L, whereby the D-isomer has no anthelmintic activity and
L-isomer (levamisole) has anthelmintic activity.
Tetramisol 10% and 20% is a broad-spectrum anthelmintic,
effective against nematodes in the gastrointestinal tract and lungs,
including Haemonchus sp., Ostertagia sp., Trichostrongylus spp.,
Nematodirus sp., Bunostomum sp., Oesophagostomum sp., Cooperia sp.,
Dictyocaulus sp., Ascaris suum, Strongyloides ransomi, Metastrongylus
sp., Oesophagostomum sp., Ascaridia, Capillaria spp., etc. Tetramisole causes stimulation of ganglia and central nervous system,
inhibits activity of fumarate reductase and succinate reductase, which
leads to paralysis and death of parasites.
After oral administration, Tetramisol 10% and 20% is quickly
absorbed in the gastrointestinal tract. The therapeutic concentration
in the organs and tissues is reached in 1-3 hours and persists for at
least 24 hours. Tetramisol 10% and 20% is excreted mainly in the
urine and partially in the feces.
Indications
• treatment and prevention of dictyocaulosis, haemonchosis, bunostomosis, nematodiros, ostertagiosis, chabertiosis, coope- riosis, strongyloidiasis in cattle, sheep and goats.
• treatment and prevention of ascariasis, oesophagostomosis, strongyloidiasis, trichuriasis, metastrongylosis in pigs;
• treatment and prevention of ascaridiosis, capillariasis, heterakidosis, amidostomosis and gape in poultry.
Composition
1 g contains 100 or 200 mg of tetramisole hydrochloride.
Dosage
The drug is administered once by oral route via drinking water or morning feeding individually or to groups at the following doses:
|
Animal species |
Dose mg/kg |
||
|
Active substance |
Tetramisole |
||
|
10% |
20% |
||
|
Cattle |
8.0 |
80.0 |
40.0 |
|
Sheep |
7.5 |
75.0 |
37.5 |
|
Pigs |
10.0 |
100.0 |
50.0 |
|
Poultry |
20.0 |
200.0 |
100.0 |