Tiacyclin®
Solution for injection intramuscular administration
Specification
Tiacyclin® solution for injection is an antibacterial drug.
Tiamulin is a macrolide antibiotic. It is active against Mycoplasma
spp. (M. hyopneumoniae, M. hyorhinis, M. hyosynoviae, M. synoviae,
M. meleagridis), Spirochaetas spp. (Brachyspira hyodysenteriae,
B. innocents, B. suis), most gram-positive and gram-negative bacteria,
including Streptococcus spp., Staphylococcus spp., Arcanobacterium
(Corynebacterium), Actinobacillus pleuropneumoniae, Clostridium
perfringens, Lawsonia intracellularis, Mannheimia haemolitica,
Pasteurella spp., Leptospira spp., Haemophillus spp., Bacterioides spp.
Forming a physiologically inactive initiation complex, tiamulin
blocks the first peptide-bond formation at the ribosomal level. The
molecule of tiamulin is located in the peptidyl transferase center of
the 50S ribosomal subunit.
Doxycycline is a tetracycline antibiotic. It is active against grampositive bacteria (Staphylococcus spp., Streptococcus spp., Actinomyces
spp., Clostridium spp., Bacillus anthracis, Corynebacterium spp.,
Erysipelothrix spp., Listeria spp.) and gram-negative bacteria
(Haemophilus influenza, Haemophilus parasuis, Pasteurella multocida,
Bordetella spp., Bartonella spp., Actinobacillus pleuropneumoniae,
Campylobacter spp.), Mycoplasma spp. (M. hyopneumoniae, M. hyorhinis,
M. hyosynoviae, M. synoviae) and Spirochaetas spp., Chlamydia spp.,
Rickettsia spp.
Disrupting the binding of the aminoacyl-tRNA to the 30S ribosomal
subunit, doxycycline inhibits protein synthesis in a bacterial cell.
Due to the inhibition of protein synthesis at different stages, the
combination of tiamulin and doxycycline causes a synergistic effect
on microorganisms.
After intramuscular administration of TIACYCLIN® solution for
injection, tiamulin and doxycycline are absorbed from the injection
site and distributed to all organs and tissues, where they provide
therapeutic concentration for 24 hours.
Tiamulin is excreted mainly in the bile and to a lesser extent in the
urine. Doxycycline is mainly excreted in the bile.
Indications
Tiacyclin® solution for injection is used to treat pigs, calves, lambs
and goatlings for bacterial diseases caused by bacteria sensitive to
tiamulin and doxycycline.
Composition
1 ml of solution for injection contains 100 mg of
doxycycline, 100 mg of tiamulin and excipients – up to 1 ml.
Dosage
Solution for injection is administered to pigs, calves,
lambs and goatlings at a dose of 1-2 ml per 25 kg bw once a day for
3-5 days.