Specification
Tilmicosin is a macrolide antibiotic, has a broad-spectrum activity
against gram-positive and gram-negative bacteria, including
Streptococcus spp., Staphylococcus spp., Pasteurella spp., Bordetella spp.,
Brachyspira spp., Mycoplasma spp., Actinobacillus pleuropneumoniae,
Clostridium spp., Ornithobacterium hinotracheale, Corynebacterium
pyuogenes, Manheimia haemolitica, etc.
Tilmicosin has a bacteriostatic effect. The antibiotic inhibits protein
synthesis in the bacterial cell at the ribosomal level.
After oral administration, the drug is well absorbed in the
gastrointestinal tract and distributed to most organs and tissues. The
maximum concentration in the blood serum is reached in 2-3 hours.
The therapeutic concentration persists for 24 hours. Tilmicosin is
excreted mainly intact, mostly in the feces and partially in the urine.
Indications
Tilmipul® is used for treatment and prevention of bacterial diseases of the gastrointestinal and respiratory tract, including mycoplasmosis, pleuropneumonia, caused by Actinobacillus pleuropneumonia, pasteurellosis, ornithobacteriosis in poultry, pigs and calves.
Composition
1 ml contains active substance: 250 mg of tilmicosin in phosphate form; excipients: 300 mg of propylene glycol, 10 ml of benzyl alcohol and purified water – up to 1 ml.
Dosage
Tilmipul® is administered individually or to groups via drinking water at the following doses:
• poultry: 300 ml per 1000 L of water (75 mg of tilmicosin per 1 L) for 3 days;
• pigs: 800 ml per 1000 L of water (200 mg of tilmicosin per 1 L) for 3 days;
• calves: via drinking water or milk replacer at a dose of 12.5 mg of tilmicosin per 1 kg bw (0.5 ml of the drug per 10 kg bw) for 3-5 days.