Amoxiprem 200 is an antibacterial drug, belongs to β-lactam antibiotics. Amoxicillin trihydrate is a semisynthetic antibiotic of the penicillin class. It is a broad-spectrum antibiotic, active against gram-positive (Actinomyces spp., Bacillus antracis, Clostridium spp., Corynebacterium spp., Erysipelothrix rhusiopathiae, Streptococcus spp., Staphylococcus spp. Listeria monocytogenes, etc.) and gram-negative bacteria (Actinobacillus spp., Bordetella bronchiseptica, Fusobacterium spp., Haemophilus spp., Moraxella spp., Pasteurella spp., Salmonella spp., etc.). Due to the bactericidal effect, the antibiotic inhibits transpeptidase activity, which leads to death of bacteria. After oral administration, amoxicillin is quickly absorbed in the gastrointestinal tract and distributed to all organs, tissues and liquids. The therapeutic concentration persists for 24 hours. The antibiotic is metabolized in the liver and forms inactive penicilloic acid, excreted primarily intact in the urine and to a lesser extent in the bile and partially in the milk.
Amoxiprem 200 is used for treatment and prevention of diseases of gastrointestinal and respiratory tract, genitourinary system and other bacterial diseases in calves, pigs and poultry, caused by amoxicillinsensitive bacteria.
1 g contains 200 mg of amoxicillin trihydrate and excipients.
Amoxiprem 200 is administered via feed at the following doses:
• calves: 50-75 mg/kg bw (10-15 mg of amoxicillin per 1 kg bw) for 10-15 days; • pigs: 50-100 mg/kg bw (10-20 mg of amoxicillin per 1 kg bw) or 1.0-1.5 kg per 1 t of feed for 10-15 days
• poultry: 100 mg/kg bw (20 mg of amoxicillin per 1 kg bw) or 1.0 kg per 1 t of feed for 5-7 days.