(propofol) solution for injection
ANESTOFOL® 1% is used to maintain short-term anesthesia, as well as induction and general anesthesia in dogs.
1 ml of ANESTOFOL® 1% contains: active substances – 10 mg of propofol, 25 mg of L-arginine, 7 mg of tocopherol acetate, 1 mg of lidocaine hydrochloride, 1 mg of sodium metabisulphite;
Excipients – 0.1 mg of macrogol 15 hydroxystearate, 0.1 mg of trilon B, 100 mg of dimethylacetamide, 0.01 mg of benzyl alcohol and water for injection.
ANESTOFOL® 1% is administered intravenously at the following doses:
for short-term anesthesia:
• without premedication: 0.5-0.7 ml of the drug per 1 kg bw, it is equal to 5-7 mg of propofol per 1 kg bw;
• with premedication: 0.4 ml of the drug per 1 kg bw, it is equal to 4 mg of propofol per 1 kg bw). for general anesthesia:
The drug is administered until the desired anesthetic depth is reached. The drug is administered at a dose of 8 mg of propofol per 1 kg bw depending on animal species and individual sensitivity. To maintain the anesthesia during the surgical procedure, ANESTOFOL® 1% is administered at a dose of 10 mg/kg/h.
It is recommended to perform osteosynthesis and prolonged abdominal operations together with simultaneous administration of analgesic agents, due to the evident hypnotic effect and weak analgesic effect of propofol.
For the induction of anesthesia prior to the inhalation anesthesia, ANESTOFOL® 1% is administered at the same dose as for the short-term anesthesia. When using ANESTOFOL® 1% the original concentration of anesthetic gas should be higher than when using barbiturates.
Propofol has no significant vagolytic effect, its administration can be accompanied with a chronotropic effect manifested in evident bradycardia and asystole, so it is reasonable to administer anticholinergic drugs, in particular atropine, prior to the administration of ANESTOFOL® 1%. In case of the occurrence of evident arterial hypotension after the administration of propofol, the administration of infusion solutions can be necessary to set the circulating blood volume and reduce the infusion rate of propofol.