Clavuxicin®
Oral powder
Specification
Clavuxicin® is an antibacterial drug. Amoxicillin trihydrate has a broad-spectrum bactericidal effect on gram-positive and gram-negative bacteria, Esherichia coli, Clostridium spp., Fusobacterium spp., Erysipilotrix spp., Bordetella spp., Staphylococcus spp., Streptococcus spp., Actynomyces spp., Corynebacterium spp., Salmonella spp., Haemophilus spp., Pasteurella spp., Actinobacillus spp., etc. The antibiotic has no effect on penicillin-producing strains, Klebsiella spp., Enterobacter spp. and Pseudomonas spp. Amoxicillin inhibits bacterial cell wall synthesis, activity of transpeptidase and carboxypeptidases, disrupts osmosis. It causes death of bacteria at the growth stage. Clavulanic acid is an irreversible inhibitor of betalactamase of bacterial cells, prevents inactivation of amoxicillin by bacterial enzymes. Due to the synergistic effect of amoxicillin and clavulanic acid, the drug is active against penicillin-resistant bacteria. After oral administration, the drug is well absorbed in the gastrointestinal tract and distributed to all organs and tissues. The therapeutic concentration persists for 12 hours. The drug is mainly excreted in the urine.
Indications
Clavuxicin® is used for treatment and prevention of gastrointestinal and respiratory diseases, genitourinary infections, skin infections, soft-tissue infections and other bacterial diseases in calves, pig and poultry caused by bacteria sensitive to the drug components.
Composition
1 g contains active substances: 500 mg of amoxicillin in trihydrate from, 125 mg of clavulanic acid in the form of potassium salt; excipients: sodium carbonate, sugar, EDTA – up to 1 g.
Dosage
Clavuxicin® is administered individually or to groups for 3-5 days.
• poultry: via drinking water, at a dose of 4 g of the drug per 100 kg bw per day. In severe cases, the dose may be doubled. The drug solution must be prepared twice a day with a 12-hour interval, the daily dose must be divided into two doses
• pigs: via drinking water, milk or feed, at a dose of 0.8-2 g of the drug per 100 kg bw, twice a day with a 12-hour interval
• calves: via water, milk or milk replacer, at a dose of 0.8 g of the drug per 100 kg bw, twice a day with a 12-hour interval.