Klindaspectin®

Specification

Clindamycin hydrochloride is an antibiotic of the lincosamide class,
has a bacteriostatic effect on gram-positive bacteria, including
penicillinase-producing strains; aerobic non-spore-forming and
spore-forming bacteria; anaerobic spore-forming bacteria and some
gram-negative microorganisms and Mycoplasma spp.
Spectinomycin hydrochloride is an antibiotic of the aminocyclitol
class. Depending on the concentration, it has both bacteriostatic
and bactericidal effect. The antibiotic is active against grampositive and gram-negative bacteria, including Salmonella spp. and
Escherichia coli.
The combination of clindamycin and spectinomycin has a synergistic
effect on gram-positive and gram-negative bacteria: Staphylococcus
spp., Streptococcus spp., Escherichia coli, Salmonella spp., Pasteurella
multocida, Haemophilus spp., Proteus spp., Shigella spp., Klebsiella
spp., Bordetella spp. and Mycoplasma spp.
Clindamycin and spectinomycin inhibit the assembly of polypeptide
chains at the 50S and 30S ribosomal subunit. It causes the inhibition
of protein synthesis and death of bacteria.