Clindamycin hydrochloride is an antibiotic of the lincosamide class,
has a bacteriostatic effect on gram-positive bacteria, including
penicillinase-producing strains; aerobic non-spore-forming and
spore-forming bacteria; anaerobic spore-forming bacteria and some
gram-negative microorganisms and Mycoplasma spp.
Spectinomycin hydrochloride is an antibiotic of the aminocyclitol
class. Depending on the concentration, it has both bacteriostatic
and bactericidal effect. The antibiotic is active against grampositive and gram-negative bacteria, including Salmonella spp. and
The combination of clindamycin and spectinomycin has a synergistic
effect on gram-positive and gram-negative bacteria: Staphylococcus
spp., Streptococcus spp., Escherichia coli, Salmonella spp., Pasteurella
multocida, Haemophilus spp., Proteus spp., Shigella spp., Klebsiella
spp., Bordetella spp. and Mycoplasma spp.
Clindamycin and spectinomycin inhibit the assembly of polypeptide
chains at the 50S and 30S ribosomal subunit. It causes the inhibition
of protein synthesis and death of bacteria.
Klindaspectin® water-soluble powder is used for treatment and prevention of bacterial infections in poultry, including colibacillosis associated with mycoplasmosis.
1 g of the drug contains 133 mg of clindamycin hydrochloride and 400 mg of spectinomycin.
Klindaspectin® water-soluble powder is administered at a dose of 150 mg/kg bw. It is administered via drinking water at a dose of 800 g per 1000 L of water. The treatment course is 5-7 days.