Neomycin sulfateis a broad-spectrum antibiotic of the aminoglycoside class. It is active against gram-positive and gramnegative bacteria, including Escherichia coli, Salmonella spp., Proteus spp., Staphylococcus spp., Corinebacterium spp., Listeria spp. and Bacillus anthracis. Protozoa, fungi and most Pseudomonas aeruginosa strains are resistant to Neomycin sulfate. The antibiotic has a bactericidal effect, inhibits protein synthesis at the bacterial ribosomes. After oral administration, Neomycin sulfate is hardly absorbed, the bactericidal effect is mainly provided in the gastrointestinal tract. The drug is excreted primarily in the feces and partially in the urine.
Neomycin sulfate is used for treatment and prevention of gastrointestinal diseases, colibacillosis, salmonellosis, gastroenterocolitis of bacterial etiology in calves, piglets, lambs and poultry.
1 g of the drug contains not less than 680 mg of neomycin sulfate.
Neomycin sulfate is administered by oral route via feed or water (milk) 2-3 times a day at a daily dose of 10-20 mg per 1 kg bw for 3-7 days.