Specification
Oxylong® 20% retard belongs to tetracycline antibiotics. Oxytetracycline is a broad-spectrum antibiotic. It has a bacteriostatic effect on most gram-positive and gram-negative bacteria, including Streptococcus spp., Staphylococcus spp., Escherichia coli, Salmonella spp., Pasteurella spp., Clostridium spp., Actinobacillus spp., Mycoplasma spp., Rickettsia spp., Chlamydia spp., Proteus spp., Fusobacterium necrophorum, Bacteroides spp. Oxytetracycline binds to the 30S subunit of bacterial ribosome, inhibits the binding of tRNA to the mRNA-ribosome complex. It results in the inhibition of protein synthesis and death of bacteria. After intramuscular administration, oxytetracycline is distributed to the blood, most organs and tissues. The maximum concentration is reached in 30-60 minutes after administration and persists for 12 hours. The therapeutic concentration persists for 96 hours. Oxytetracycline is metabolized and excreted intact primarily in the bile and urine and partially in the milk of lactating animals.
Indications
Oxylong® 20% retard is used to treat cattle, sheep and pigs for diseases of gastrointestinal, urinary and respiratory tract, musculoskeletal system, mastitis, postoperative, wound and other primary and secondary infections caused by oxytetracycline-sensitive bacteria.
Composition
1 ml retard contains active substance: 200 mg of oxytetracycline (in the form of dihydrate); excipients: 15.1 mg of magnesium oxide, 2 mg of rongalite, 300 mg of soluphor, 1-N-methyl-2- pyrrolidone, ascorbic acid kollidon and water for injection – up to 1 ml.
Dosage
Oxylong® 20% retard is administered to cattle, sheep and pigs once
by intramuscular route at a dose of 1 ml per 10 kg bw (20 mg of the
active substance per 1 kg bw).
The maximum dose for piglets weighing less than 10 kg is 1 ml per
animal. To treat atrophic rhinitis, the drug is administered at the same
dose thrice on 3, 12 and 21 day.
If the drug volume exceeds 20 ml for cattle, 10 ml for pigs and
5 ml for calves and sheep, the antibiotic must be administered to
several injection sites.