Specification
Closantel is a broad-spectrum antiparasitic drug, active against
trematodes, nematodes and botfly larvae. The drug has an effect
on larval and mature stages of Fasciola hepatica and mature stage
of Bunostomum sp., Haemonchus contortus, Haemonchus placei,
Oesophagostomum radiatum, Chabertia ovis and larvae of Hypoderma
bovis and Oestrus ovis.
Closantel inhibits the process of phosphorylation and electron
transport, which leads to the inhibition of energy metabolism. It
causes paralysis and death of parasites.
After intramuscular administration, closantel is quickly absorbed
from the injection site and distributed to most organs and tissues.
The maximum concentration is reached in 12 hours and persists for
24-36 hours, the therapeutic concentration – for 10-11 days.
Closantel is primarily excreted intact in the feces, urine and milk.
Indications
The drug is used to treat cattle and sheep for fasciolosis, haemonchosis, bunostomosis, chabertiosis, oesophagostomosis, trichostrongyloidosis, hypodermyasis, oestrosis.
Composition
1 ml contains 50 or 100 mg of closantel respectively
Dosage
Santel® 5% and 10% solution for injection is administered to cattle once by intramuscular route, to sheep and goats – by subcutaneous route. For better absorption, it is recommended to heat the vial to 37 °C. If one injection exceeds 20 ml, it is recommended to administer the drug to several injection sites.
Santel® 5% and 10% solution for injection is administered at the following doses:
|
Animal species |
Parasite |
Dose Mg/kg |
Dose of 5% ml/10 kg |
Dose of 10% ml/10 kg |
|
Cattle |
Bunostomum sp. |
2.5-5.0 |
0.5-1.0 |
0.25-0.5 |
|
Fasciola gigantica |
2.5 |
0.5 |
0.25 |
|
|
Fasciola hepatica |
2.5-5.0 |
0.5-1.0 |
0.25-0.5 |
|
|
Haemonchus placei Haemonchus contortus |
2.5 |
0.5 |
0.25 |
|
|
Oesophagostomum radiatum |
2.5-5.0 |
0.5-1.0 |
0.25-0.5 |
|
|
Hypoderma bovis |
5.0 |
1.0 |
0.5 |
|
|
Sheep |
Chabertia ovis |
5-10 |
1.0-2.0 |
0.5-1.0 |
|
Fasciola gigantica |
5-10 |
1.0-2.0 |
0.5-1.0 |
|
|
Fasciola hepatica |
5-10 |
1.0-2.0 |
0.5-1.0 |
|
|
Oesophagostomum radiatum |
5 |
1.0 |
0.5 |
|
|
Haemonchus placei Haemonchus contortus |
2.5-5.0 |
0.5-1.0 |
0.25-0.5 |
|
|
Oestrus ovis |
5 |
1.0 |
0.5 |