The drug has broad-spectrum antiparasitic activity, effective against nematodes in the gastrointestinal tract and lungs, trematodes, botfly larvae and actoparasites. Closantel inhibits the process of phosphorylation and electron transport, which leads to the inhibition of energy metabolism. It causes paralysis and death of parasites. Ivermectin stimulates secretion of gamma-aminobutyric acid (GABA) in presynaptic neurons, which binds to the specific receptors of nerve endings by increasing membrane permeability to chloride ions and inhibits transmission of neuromuscular pulses. This causes paralysis and death of parasites. After parenteral administration, the active substances are well absorbed from the injection site and distributed to most organs and tissues. The therapeutic concentration persists for 10-12 days. The drug is excreted in the urine, bile, feces and partially in the milk.
The drug is used to treat cattle, sheep, goats, deer for dictyocaulosis, haemonchosis, ostertagiosis, trichostrongyloidosis, cooperiosis, nematodiros, oesophagostomosis, bunostomosis, strongyloidiasis, fasciolosis, thelaziasis, hypodermyasis, oestrosis, sifunculatoses, sarcoptoses, psoroptic mange, chorioptic mange.
1 ml contains 5 mg of ivermectin and 125 mg of closantel.
The drug is administered to cattle, sheep, goats and deer by subcutaneous or intramuscular injection to the subscapular region. Santomectin® solution for injection is administered once at a dose of 1 ml of the drug per 50 kg bw (0.1 mg of ivermectin and 2.5 mg of closantel per 1 kg bw).