Specification
Soladoxy® 500 is an antibacterial drug.
Doxycycline is a semisynthetic antibiotic, belongs to the tetracycline
class. The antibiotic has a broad-spectrum antibacterial effect on
gram-positive (Staphylococcus spp., Streptococcus spp., Actinomyces spр.,
Clostridium spp., Bacillus anthracis, Corynebacterium spp., Erysipelothrix
spp., Listeria spp.) and gram-negative bacteria (Haemophilus influenzae,
Haemophilus parasuis, Pasterurella multocida, Bordetella spр., Brucella
spр., Bartonella spр., Actinobacillus pleuropneumoniae, Escherichia coli,
Salmonella spp., Сampylobacter spp.) and Mycoplasma spp. (M. synoviae,
M. hyopneoumonia, M. hyorhinis, M. hyosynoviae), Spirochaetas spp.,
Chlamydia spp. and Rickettsia spp. The drug has a bacteriostatic effect.
Doxycycline inhibits bacterial protein synthesis, disrupts the binding
of aminoacyl-tRNA to the 30S ribosomal subunit.
After oral administration, doxycycline is well absorbed in the
gastrointestinal tract and distributed to all organs and tissues. The
maximum concentration is reached in 2-4 hours. The therapeutic
concentration persists 18-24 hours.
Doxycycline is mainly excreted in the bile.
Indications
Soladoxy® 500 is used for treatment and prevention of respiratory and gastrointestinal diseases of bacterial etiology in calves, lambs, goatlings, pigs and poultry caused by doxycycline-sensitive bacteria.
Composition
1 g contains active substance: 500 mg of doxycycline hyclate; excipients: 100 mg of ascorbic acid, 380 mg of lactose, 10 mg of sodium metabisulphite and 10 mg of trilon B.
Dosage
Soladoxy® 500 is administered via drinking water for 3-5 days:
• calves, lambs and goatlings – individually, at a dose of 1 g of the drug per 100 kg bw (5 mg of doxycycline per 1 kg bw), twice a day
• pigs and poultry – to groups, at a dose of 100 g of the drug per 500-1000 L of drinking water.