Spelinc® 660
Oral powder
Specification
Spelinc® 660 is an antibacterial drug.
Spectinomycin is an aminocyclitol antibiotic. It has a bacteriostatic
effect on gram-negative bacteria, including Escherichia coli,
Salmonella spp.
Spectinomycin inhibits protein synthesis at the ribosomal level
through binding to the 30S ribosomal subunit.
Lincomycin hydrochloride is a lincosamide antibiotic. It has
a bacteriostatic effect mostly on gram-positive bacteria:
Staphylococcus spp., Streptococcus spp. (including penicillinaseproducing microorganisms), Corynebacterium spp., Clostridium spp.,
and Bacteroides spp. и Mycoplasma spp.
Lincomycin inhibits protein synthesis at the ribosomal level through
binding to the 50S ribosomal subunit.
The combination of spectinomycin and lincomycin has a synergistic
effect on gram-positive and gram-negative bacteria, including
Escherichia spp., Salmonella spp., Bordetella spp., and Brachyspira
(Serpulina) hyodysenteriae, Mycoplasma spp.
After oral administration, lincomycin is absorbed in the
gastrointestinal tract and distributed to most organs and tissues.
The maximum concentration in the blood is reached in 3-6 hours
after administration. Spectinomycin is poorly absorbed and has its
antimicrobial effect directly in the intestine.
Lincomycin and spectinomycin are excreted intact mainly in the
urine and feces.
Indications
Spelinc® 660 is used for treatment and prevention of colibacillosis, salmonellosis and dysentery in pigs and salmonellosis, colibacillosis and mycoplasmosis in chickens.
Composition
1 g contains active substances: 440 mg of spectinomycin hydrochloride and 220 mg of lincomycin hydrochloride; excipient: lactose – up to 1 g.
Dosage
Spelinc® 660 is administered individually and to groups via drinking water or feed at the following doses:
• pigs: 90-100 g per 1000 L of water for 7 days
• poultry: 500-1000 g per 1000 L of water for 3-7 days.