Sulteprim® oral solution is an antibacterial drug, has a broad-
spectrum activity against most gram-positive and gram-negative
bacteria, including E. coli, Salmonella spp., Staphylococcus spp.,
Streptococcus spp., Shigella spp., Haemophilus spp., Pasteurella spp., etc.,
some protozoa (Coccidia and Toxoplasma gondii). Sulfadimezine is a
sulfanilamide agent. In structure, it is similar to para-aminobenzoic
acid. Sulfadimezine inhibits dihydrofolic acid synthesis in the
bacterial cell, prevents inclusion of para-aminobenzoic acid in its
molecule. Trimethoprim is a synthetic antibiotic. It enhances the
effect of sulfadimezine through reduction of dihydrofolic acid to
tetrahydrofolic acid – active form of folic acid – responsible for
protein metabolism and bacterial division. The synergistic bactericidal
effect of the combination inhibits folic acid synthesis, which leads to
the inhibition of nucleotide synthesis.
Sulfadimezine and trimethoprim are well and quickly absorbed in
the gastrointestinal tract and distributed to all organs and tissues.
The antibacterial concentration persists for 24 hours. Sulfadimezine
and trimethoprim are excreted primarily in the urine and to a lesser
extent in the bile.
Sulteprim® oral solution is used to treat poultry for colibacillosis, salmonellosis, pasteurellosis, staphylococcosis, coccidiosis; calves, lambs, goatlings – for colibacillosis, salmonellosis, pasteurellosis, bronchopneumonia, abscesses, polyarthritis of bacterial etiology; pigs – for colibacillosis, atrophic rhinitis, haemophillosis, pleuropneumonia, caused by Actinobacillus pleuropneumonia.
1 ml contains active substances: 200 mg of sulfadimezine, 40 mg of trimethoprim or 400 mg of sulfadimezine and 80 mg of trimethoprim; excipients: soluphor, N-methyl-2-pyrrolidone, sodium hydroxide, benzyl alcohol, sodium thiosulfate, disodium edetate and purified water.
Sulteprim® oral solution is administered individually and to groups by oral route at the following doses:
• poultry: via drinking water for 3-5 days, coccidiosis – 2 L per 1000 L of water, other diseases – 0.5-1.0 L per 1000 L of water;
• calves, lambs and goatlings: via drinking water or milk replacer at a daily dose of 1-2 ml per 16 kg bw. The treatment course is 5 days.
• pigs: via drinking water at a dose of 0.5-1.0 L per 1000 L of water for 3-5 days.
If necessary, the daily dose for calves, goatlings and lambs can be divided into two doses administered with a 12-hour interval.