Tiacyclin oral solution is a combined antibacterial drug. In combination, tiamulin and doxycycline have a mutually reinforcing effect on microorganisms by inhibiting protein synthesis in the microbial cell at different stages. Tiamulin is a macrolide antibiotic. It is active against Mycoplasmas (Micoplasma hyopneumoniae, M. hyorhinis, M. hyosynoviae, M. synoviae, M. meleagridis), Borrelia (Brachyspira hyodysenteriae, B. innocents, B. suis), many gram-positive and gram-negative bacteria, including Streptococcus spp., Staphylococcus spp., Arcanobacterium (Corynebacterium), Actinobacillus pleuropneumoniae, Clostridium perfringens, Lawsonia intracellularis, Mannheimia haemolytica, Pasteurella spp., Leptospira spp., Haemophillus spp., Bacteroides spp. and etc. Forming a physiologically inactive initiation complex, tiamulin blocks the first peptide-bond formation at the ribosomal level. The molecule of tiamulin is located in the peptidyl transferase center of the 50S ribosomal subunit. Doxycycline is a tetracycline antibiotic. It is active against grampositive bacteria (Staphylococcus spp., Streptococcus spp., Actinomyces spp., Clostridium spp., Bacillus anthracis, Corynebacterium spp., Erysipelothrix spp., Listeria spp.) and gram-negative microorganisms (Haemophilus influenza, Haemophilus parasuis, Pasteurella multocida, Bordetella spp., Bartonella spp., Actinobacillus pleuropneumoniae, Campylobacter spp.), as well as Mycoplasmas (Micoplasma hyopneumoniae, M. hyorhinis, M. hyosynoviae, M. synoviae), Borrelia, Chlamydia and Rickettsia. Disrupting the binding of the aminoacyl-tRNA to the 30S ribosomal subunit, doxycycline inhibits protein synthesis in a bacterial cell. After oral administration of TIACYCLIN solution, tiamulin and doxycycline are well and quickly absorbed and distributed to all organs and tissues of the body, where they provide therapeutic concentration for 24 hours. Tiamulin is excreted mainly in the bile and to a lesser extent in the urine. Doxycycline is mainly excreted in the bile.
Tiacyclin oral solution is used to treat pigs, calves, lambs and kids, poultry for bacterial diseases (pasteurellosis, colibacillosis, salmonellosis, etc.), the pathogens of which are sensitive to thiamulium and doxycycline.
1 ml contains 100 mg of doxycycline, 100 mg of tiamulin and excipients.
Tiacyclin oral solution is administered once a day for 3-5 days at the following doses:
calves, lambs and kids: 1-2 ml per 25 kg bw;
pigs: 1-2 ml per 25 kg bw or 0.5-1 L per 1000 L of drinking water, in severe cases – 2 L per 1000 L of drinking water.
poultry: 0.5-1 L per 1000 L, in severe cases – 2 L per 1000 L of drinking water. The solution of the drug is prepared for poultry based on the need for water for one day. During the treatment period, the poultry should receive only water, containing the drug.