Tiamulin and doxycycline are effective against Mycoplasma spp.
(Mycoplasma hyopneumoniae, M. hyorhinis, M. hyosynoviae, M. synoviae, M. meleagridis), Spirochaetas spp. (Brachyspira hyodysenteriae,
B. innocents, B. suis), most gram-positive and some gram-negative
bacteria, including Streptococcus spp., Staphylococcus spp.,
Bacillus anthracis, Erysipelothrix spp., Listeria spp., Arcanobacterium
(Corynebacterium), Actinobacillus pleuropneumoniae, Clostridium
perfringens, Lawsonia intracellularis, Mannheimia haemolitica, Pasteurella
spp., Leptospira spp., Haemophilus spp, Bordetella sp., Brucella sp.,
Bartonella sp., Actinobacillus pleuropneumoniae, Сampylobacter spp.,
After a single administration, the high therapeutic concentration
persists for 24 hours.
Tiamulin is excreted mainly in the bile and to a lesser extent in the
urine. Doxycycline is mainly excreted in the bile.
The drug is used for treatment and prevention of dysentery, atrophic rhinitis, enzootic pneumonia, pleuropneumonia, haemophillosis, intestinal spirochetosis, salmonellosis, colibacillosis, necrotic enteritidis in pigs caused by bacteria sensitive to tiamilin and doxycycline.
1 g contains 50 mg of doxycycline hydrochloride and 50 mg of tiamulin hydrogen fumarate.
Tiacyclin® ® is administered individually or to groups via feed at the following doses:
• for treatment: 2.5-3 kg of the drug per 1 t per day for 5 days
• for prevention: 2-2.5 kg of the drug per 1 t per day for 5-10 days.